The goal of the project is to utilize affinity proteomics to develop novel immunoassays to improve the diagnosis of different types of dementias.
Your main tasks and responsibilities in this project will be to:
- Develop customized panels of immunoassays for analysis of novel biomarker candidates;
- Optimize these panels for biomarker detection in both cerebrospinal fluid and blood using state-of-the-art technologies;
- Technically and clinically validate these novel tests in relevant patient samples from different cohorts;
- Process and analyse the data;
- Communicate results by means of oral presentations and scientific publications;
- Perform a secondment (internship) at Olink Proteomics AB (Uppsala, Sweden) to develop statistical methods for unsupervised cluster analysis to discover molecular pathways underlying different dementias and their subtypes.
We look for excellent candidates with a M.Sc. degree in Biology, Chemistry, Biotechnology or related fields.
The primary host of the project is: KTH Royal Institute of Technology, Stockholm, Sweden.
As early stage researcher you will work in close collaboration with Prof. Peter Nilsson and Dr. Anna Månberg who together head the neuroproteomic research performed at the Division of Affinity Proteomics, Department of Protein Science at KTH. The group is focused on protein and autoimmunity profiling using array technologies and located at SciLifeLab (www.scilifelab.se), a national resource of unique technologies and expertise and have long experience in biomarker discovery research in close collaboration with clinical experts. The group also works closely with the Human Protein Atlas (www.proteinatlas.org), enabling access to the extensive collection of affinity reagents to be used for exploration and evaluation of disease associated protein profiles.