Early Stage Researcher 12

Novel immunoassay for Neurofilament Light

The goal of the project is to develop a novel immunoassay for Neurofilament light in CSF and blood.


Your main tasks and responsibilities in this project are:

- To develop an immunoassay for the analysis of Neurofilament light as biomarker in CSF and plasma;

- To validate the novel biomarker assay with respect to analytical, clinical and intellectual property characteristics for its context of use according to pharma requirements;

- To organise, perform and analyse clinical studies using the novel immunoassay for specific context-of-use;

- To generate a guidance for collection and storage of blood samples, using data generated with the qualified assay;

- To communicate results by means of oral presentations and scientific publications;

- To prepare a marketing/business case for commercialization of the assay;

- Perform a secondment (Internship) of 3 months at the Department of Clinical Chemistry, Amsterdam UMC location VUmc, to analyse clinical samples and define cut-points and context of use in trials and clinical practice.


We look for excellent candidates that are keen for research and that are eager to translate scienific findings into useful tools for the research field and community. A M.Sc. degree in Biology, Chemistry, or related fields is a must, a sense for business is a plus.


The primary host of the project is: ADx NeuroSciences N.V., Belgium

As early stage researcher you work at ADx NeuroSciences, Belgium in close collaboration with the head of the research group (dr. Eugeen Vanmechelen), at Amsterdam UMC, the Netherlands with postdoc dr. Eline Willemse and Prof. Charlotte Teunissen. You will be part of a young, multidisciplinary team, with ample experience, and an excellent position within the expert field of biomarker development. During your project, you will be trained in various aspects, from performing high end research up to getting introduced to business (incl. patents & patent applications) and enterpreneurship.