The goal of the project is to integrate existing –omics data for identification of pathways and candidate biomarkers for differential dementia diagnosis. A big data integration platform and a protein catalogue will be generated. A Dementia Disease Map will be developed to generate novel hypotheses of early stage pathobiology of dementias.
Your main tasks and responsibilities
- To integrate available (public and own) datasets of dementia and to make them available to the consortium and the broad research audience via a dedicated data platform;
- To screen these integrated datasets for candidate biomarker molecules;
- To develop a Dementia Disease Map based on the key dementia mechanisms, candidate molecules and existing knowledge repositories;
- To propose new protein-antibody interaction algorithms based on the collected data and disease map;
- To communicate results by means of oral presentations and scientific publications.
We look for excellent candidates with a M.Sc. degree in Bioinformatics, Biology, Chemistry, or related fields.
The primary host of the project is: Bioinformatics Core at the Luxembourg Centre for Systems Biomedicine (LCSB) is a dynamic team working in the area of translational medicine. We offer our expertise and infrastructure for biomedical data integration and visualization to our centre, but also national and international partners. The research group has strong expertise in developing standardized, reproducible data operations for clinical and life sciences collaborators. We also work on multi-scale disease models and approaches to combine them with available data for better understanding of disease mechanisms.